Abstract (hsc full form)
Abstract ( hsc full form ) The mammalian blood System comprises more than ten different types of mature cells, is based on one cell type: hematopoietic stem cell (HSC). Within the system there are only HSC are able to exhibit self-renewal and multi-potency. Multi-potency is the capacity to differentiate into all functional blood cells. Self-renewal can give rise to HSC that is not differentiated. Since mature blood cells are typically short lived, HSC continuously provide more differentiated progenitors while properly maintaining the HSC size appropriately throughout their lives by precisely the balance between self-renewal as well as differentiation. Therefore, understanding the mechanism of self-renewal and differentiation of HSC is a key issue. In this review, we focus on the hierarchical structure of the hematopoietic system, our current understanding of the molecular and microenvironmental cues that regulate self-renewal and di...